
Gastroesophageal Reflux Disease
Gastroenterology Hepatology
Gastroesophageal reflux disease (GERD), commonly known as acid reflux, occurs when stomach acid or stomach contents abnormally flow back into the esophagus, causing irritation and inflammation of the esophageal lining. Severe cases can significantly damage the esophageal mucosa, affecting the patient's quality of life.
Symptoms
- Heartburn (burning sensation in the chest)
- Acid reflux into the mouth
- Upper abdominal or chest discomfort
- Difficulty or pain when swallowing
- Chronic cough, throat discomfort, or hoarseness
- Nausea or vomiting
Causes and Risk Factors
Causes
- Poor functioning or relaxation of the lower esophageal sphincter (LES)
- Increased pressure in the stomach, pushing contents upward
- Delayed stomach emptying, leading to prolonged exposure to stomach acid
Risk Factors
- Unhealthy eating habits (e.g., high-fat, spicy, or irritating foods)
- Smoking and alcohol consumption
- Obesity or overweight conditions
- High stress or anxiety levels
- Hormonal changes and increased abdominal pressure during pregnancy
- Long-term use of certain medications (e.g., calcium channel blockers, antidepressants)

Potential Complications
- Esophagitis: Chronic inflammation of the esophageal mucosa
- Esophageal ulcers or bleeding
- Esophageal stricture: Narrowing due to scarring from prolonged inflammation
- Barrett's Esophagus: Cellular changes due to chronic acid exposure, increasing esophageal cancer risk
- Increased risk of esophageal cancer
Diagnosis
Clinical Symptoms and Medical History Evaluation | Doctor will thoroughly inquire about the patient's medical history and symptoms, including the frequency, duration, severity, as well as triggering and relieving factors of the symptoms. |
Gastroscopy | Gastroscopy allows direct visualization of the esophagus, stomach, and duodenum. The doctor closely examines the esophageal mucosa for signs of inflammation, redness, erosion, or ulceration to determine the severity of the condition. Additionally, endoscopy helps rule out more serious issues such as gastric ulcers, esophageal cancer, or other tumors. During the procedure, the doctor may perform a biopsy of esophageal tissues for further cellular analysis (e.g., to detect Barrett’s Esophagus). |
24-hour Esophageal pH Monitoring | Doctor inserts a thin catheter through the patient's nostril into the lower esophagus to continuously monitor the acidity (pH level) for 24 hours. Patients can engage in normal daily activities and meals during the monitoring period. The device records the frequency, duration, timing, and acidity during episodes of acid reflux, providing an accurate assessment of the severity of the condition. This method is one of the most precise diagnostic tools for gastroesophageal reflux disease (GERD). |
Esophageal Function Testing (Esophageal Manometry) | Doctor places a thin catheter with embedded sensors into the patient’s esophagus and asks the patient to perform swallowing actions. This test measures the muscle contraction strength and coordination of the esophagus and the lower esophageal sphincter (LES). Through this examination, the doctor can identify abnormalities in esophageal function, such as sphincter relaxation or weak closure, providing critical diagnostic information for GERD and assisting in evaluating suitability for surgical intervention. |
Treatments
Lifestyle and Dietary Modifications |
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Medication |
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Surgical Treatment (for severe cases or ineffective medication) |
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FAQ
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