GERD
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Gastroesophageal Reflux Disease

Gastroenterology Hepatology

Gastroesophageal reflux disease (GERD), commonly known as acid reflux, occurs when stomach acid or stomach contents abnormally flow back into the esophagus, causing irritation and inflammation of the esophageal lining. Severe cases can significantly damage the esophageal mucosa, affecting the patient's quality of life.

Symptoms

  • Heartburn (burning sensation in the chest)
  • Acid reflux into the mouth
  • Upper abdominal or chest discomfort
  • Difficulty or pain when swallowing
  • Chronic cough, throat discomfort, or hoarseness
  • Nausea or vomiting

Causes and Risk Factors

Causes 

  • Poor functioning or relaxation of the lower esophageal sphincter (LES)
  • Increased pressure in the stomach, pushing contents upward
  • Delayed stomach emptying, leading to prolonged exposure to stomach acid
     

Risk Factors

  • Unhealthy eating habits (e.g., high-fat, spicy, or irritating foods)
  • Smoking and alcohol consumption
  • Obesity or overweight conditions
  • High stress or anxiety levels
  • Hormonal changes and increased abdominal pressure during pregnancy
  • Long-term use of certain medications (e.g., calcium channel blockers, antidepressants)

Potential Complications

  • Esophagitis: Chronic inflammation of the esophageal mucosa
  • Esophageal ulcers or bleeding
  • Esophageal stricture: Narrowing due to scarring from prolonged inflammation
  • Barrett's Esophagus: Cellular changes due to chronic acid exposure, increasing esophageal cancer risk
  • Increased risk of esophageal cancer

Diagnosis

Clinical Symptoms and Medical History EvaluationDoctor will thoroughly inquire about the patient's medical history and symptoms, including the frequency, duration, severity, as well as triggering and relieving factors of the symptoms.
Gastroscopy

Gastroscopy allows direct visualization of the esophagus, stomach, and duodenum. The doctor closely examines the esophageal mucosa for signs of inflammation, redness, erosion, or ulceration to determine the severity of the condition. Additionally, endoscopy helps rule out more serious issues such as gastric ulcers, esophageal cancer, or other tumors.

During the procedure, the doctor may perform a biopsy of esophageal tissues for further cellular analysis (e.g., to detect Barrett’s Esophagus).

24-hour Esophageal pH MonitoringDoctor inserts a thin catheter through the patient's nostril into the lower esophagus to continuously monitor the acidity (pH level) for 24 hours. Patients can engage in normal daily activities and meals during the monitoring period. The device records the frequency, duration, timing, and acidity during episodes of acid reflux, providing an accurate assessment of the severity of the condition. This method is one of the most precise diagnostic tools for gastroesophageal reflux disease (GERD).
Esophageal Function Testing (Esophageal Manometry)Doctor places a thin catheter with embedded sensors into the patient’s esophagus and asks the patient to perform swallowing actions. This test measures the muscle contraction strength and coordination of the esophagus and the lower esophageal sphincter (LES). Through this examination, the doctor can identify abnormalities in esophageal function, such as sphincter relaxation or weak closure, providing critical diagnostic information for GERD and assisting in evaluating suitability for surgical intervention.

Treatments

Lifestyle and Dietary Modifications

  • Avoid spicy, fatty, acidic foods, chocolate, mint, and similar irritants
  • Eat smaller, more frequent meals; avoid overeating
  • Avoid eating at least three hours before bedtime
  • Quit smoking and alcohol consumption
  • Control body weight to avoid obesity
  • Slightly elevate the upper body while sleeping

Medication

  • Antacids: Neutralize stomach acid and relieve discomfort
  • Proton Pump Inhibitors (PPIs): Reduce stomach acid production, treating esophagitis
  • H2 blockers: Decrease stomach acid secretion

Surgical Treatment (for severe cases or ineffective medication)

  • Fundoplication: Strengthening the lower esophageal sphincter to prevent acid reflux

FAQ

GERD itself does not directly cause cancer, but prolonged acid reflux can lead to Barrett's Esophagus, which increases the risk of developing esophageal cancer.
Most patients can effectively control symptoms through lifestyle modifications and medication. However, symptoms may recur without lifestyle changes, making a complete cure difficult.
Common triggering foods include high-fat foods, spicy foods, coffee, alcohol, chocolate, mint, citrus fruits, and tomato-based products.
Depending on severity, some patients may require long-term or periodic medication to control stomach acid. As symptoms improve, physicians might gradually adjust or discontinue medications, primarily managing the condition through lifestyle changes.

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